Fission yeast genes nda1+ and nda4+, mutations of which lead to S-phase block, chromatin alteration and Ca2+ suppression, are members of the CDC46/MCM2 family.

doi:10.1091/mbc.4.10.1003

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Article

Fission yeast genes nda1+ and nda4+, mutations of which lead to S-phase block, chromatin alteration and Ca2+ suppression, are members of the CDC46/MCM2 family.

Molecular biology of the cell - 1 Oct 1993

Miyake S, Okishio N, Samejima I, Hiraoka Y, Toda T, Saitoh I, Yanagida M

Abstract excerpt

Fission yeast cold-sensitive mutants nda1-376 and nda4-108 display a cell cycle block phenotype at the restrictive temperature (cell elongation with the single nucleus) accompanied by an alteration in the nuclear chromatin region. DNA content analysis shows that the onset of DNA synthesis is bloc...

Topics

Amino Acid Sequence
Antigens, CD
Base Sequence
Calcium
Cell Cycle Proteins
Cell Division
Chromatin
Chromosome Mapping
Chromosomes, Fungal
Cloning, Molecular
DNA, Fungal
DNA-Binding Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Fungal Proteins

Genes, Fungal

Genetic Complementation Test

Membrane Cofactor Protein

Membrane Glycoproteins

Molecular Sequence Data

Source

Open in PubMed Open full text

Identifiers

PMID: 8298187
DOI: 10.1091/mbc.4.10.1003
PMCID: PMC275734

Genes

MCM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8298187-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Fission yeast genes nda1+ and nda4+, mutations of which lead to S-phase block, chromatin alteration and Ca2+ suppression, are members of the CDC46/MCM2 family.PMID 8298187Read ↗

Fission yeast Nda1 and Nda4, MCM homologs required for DNA replication, are constitutive nuclear proteins.Semantic proximity Read ↗

Fission yeast minichromosome loss mutants mis cause lethal aneuploidy and replication abnormality.Semantic proximity Read ↗

Identification of sna41 gene, which is the suppressor of nda4 mutation and is involved in DNA replication in Schizosaccharomyces pombe.Semantic proximity Read ↗

NBP1 (Nap1 binding protein 1), an essential gene for G2/M transition of Saccharomyces cerevisiae, encodes a protein of distinct sub-nuclear localization.Semantic proximity Read ↗

Fission yeast cdc24 is a replication factor C- and proliferating cell nuclear antigen-interacting factor essential for S-phase completion.Semantic proximity Read ↗

Schizosaccharomyces pombe cdc4+ gene encodes a novel EF-hand protein essential for cytokinesis.Semantic proximity Read ↗

Fission yeast cdc24(+) encodes a novel replication factor required for chromosome integrity.Semantic proximity Read ↗

The fission yeast Cdc1 protein, a homologue of the small subunit of DNA polymerase delta, binds to Pol3 and Cdc27.Semantic proximity Read ↗

The fission yeast cdc19+ gene encodes a member of the MCM family of replication proteins.Semantic proximity Read ↗

Fission yeast cdc21+ belongs to a family of proteins involved in an early step of chromosome replication.Semantic proximity Read ↗

Cdm1, the smallest subunit of DNA polymerase d in the fission yeast Schizosaccharomyces pombe, is non-essential for growth and division.Semantic proximity Read ↗

CSL protein regulates transcription of genes required to prevent catastrophic mitosis in fission yeast.Semantic proximity Read ↗

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