Article
[Mechanism of loss of androgen dependency in androgen-dependent tumor].
Human cell - 1 Sept 1993
Sato N, Suzuki H, Shimazaki J
Abstract excerpt
Human prostatic cancer is androgen sensitive tumor but gradually loses its androgen sensitivity during progression. Amount of androgen receptors usually correlates with androgen sensitivity. Mutation of androgen receptor gene is attributable to be one reason for androgen insensitivity. Alternativ...
Topics
- Androgens
- Animals
- Humans
- Male
- Mice
- Mutation
- Neoplasms, Hormone-Dependent
- Prostatic Neoplasms
- Rats
- Receptors, Androgen
- Tumor Cells, Cultured