[Androgen receptor mutation and progression of prostate cancer].

Abstract excerpt

Prostate cancer growth is almost wholly dependent on the route of the androgen receptor and most therapies aimed at blocking this signaling axis are useful tools in the management of this disease. Unfortunately such therapies invariably fail, and the cancer progresses to an androgen-independent stage. In such cases, androgen receptor mutation almost always occurs and much evidence suggests the continuous growth...

Topics

• Disease Progression
• Humans
• Male
• Mutation
• Prostatic Neoplasms
• Receptors, Androgen