Clinical characteristics in a kindred with early-onset Alzheimer's disease and their linkage to a G-->T change at position 2149 of the amyloid precursor protein gene.

doi:10.1212/wnl.44.1.105

Article

Clinical characteristics in a kindred with early-onset Alzheimer's disease and their linkage to a G-->T change at position 2149 of the amyloid precursor protein gene.

Neurology - 1 Jan 1994

Farlow M, Murrell J, Ghetti B, Unverzagt F, Zeldenrust S, Benson M

Abstract excerpt

Patients from five generations of a family developed presenile Alzheimer's disease (AD) early in the fifth decade. Recent memory, information-processing speed, sequential tracking, and conceptual reasoning were the earliest cognitive functions affected. Language and visuoperceptual skills were la...

Topics

Adult
Age of Onset
Alzheimer Disease
Amyloid beta-Protein Precursor
Base Sequence
Brain
DNA
Female
Genetic Linkage
Humans
Male
Middle Aged
Mutation
Neuropsychological Tests
Pedigree

Clinical characteristics in a kindred with early-onset Alzheimer's disease and their linkage to a G-->T change at position 2149 of the amyloid precursor protein gene.

Abstract excerpt

Topics

Discuss the evidence