Article
Early-onset Alzheimer disease caused by a new mutation (V717L) in the amyloid precursor protein gene.
Archives of neurology - 1 Jun 2000
Murrell J R, Hake A M, Quaid K A, Farlow M R, Ghetti B
Abstract excerpt
CONTEXT: Alzheimer disease is the most common form of dementia. Mutations in the genes amyloid precursor protein (APP), presenilin 1(PS1) and presenilin 2(PS2) have been found in early-onset familial forms of Alzheimer disease OBJECTIVE: To determine the cause of dementia in a family with early-onset illness. DESIGN, SETTING, AND PARTICIPANTS: A family with a history of dementia was referred to the Indiana...
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