Article
Rhabdomyosarcomas do not contain mutations in the DNA binding domains of myogenic transcription factors.
The Journal of clinical investigation - 1 Jan 1994
Anand G, Shapiro D N, Dickman P S, Prochownik E V
Abstract excerpt
Skeletal myogenesis is regulated by a group of transcription factors (MyoD, myogenin, myf5, and myf6) that are "basic helix-loop-helix" proteins that bind to the promoters of muscle-specific genes and promote their expression. We have previously shown that after a mutation of Leu122 to Arg the DNA binding basic domain of MyoD confers c-myc-like functional characteristics to the protein. In this study we used...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.