Article
Rhabdomyosarcomas do not contain mutations in the DNA binding domains of myogenic transcription factors.
The Journal of clinical investigation - 1 Jan 1994
Anand G, Shapiro D N, Dickman P S, Prochownik E V
Abstract excerpt
Skeletal myogenesis is regulated by a group of transcription factors (MyoD, myogenin, myf5, and myf6) that are "basic helix-loop-helix" proteins that bind to the promoters of muscle-specific genes and promote their expression. We have previously shown that after a mutation of Leu122 to Arg the DN...
Topics
- Amino Acid Sequence
- Base Sequence
- Binding Sites
- Cell Line
- DNA Primers
- DNA-Binding Proteins
- Genes, myc
- Humans
- Leukocytes
- Molecular Sequence Data
- Mutation
- MyoD Protein
- Myogenic Regulatory Factors
- Myogenin
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Proto-Oncogene Proteins c-myc
- Rhabdomyosarcoma