Characterization of regulatory mutations causing anaerobic derepression of the sodA gene in Escherichia coli K12: cooperation between cis- and trans-acting regulatory loci.

Abstract excerpt

The genetic loci leading to anaerobic derepression of a sodA::lacZ protein fusion in a UV-generated mutant strain (UV14) of Escherichia coli were identified. The mutant (UV14) was found to harbour two altered loci: one is in the trans-regulatory gene fnr (fumarate nitrate reduction) where leucine...

Topics

• Base Sequence
• Escherichia coli
• Gene Expression Regulation, Bacterial
• Gene Expression Regulation, Enzymologic
• Genes, Bacterial
• Genes, Regulator
• Iron Chelating Agents
• Lac Operon
• Molecular Sequence Data
• Mutation
• Regulatory Sequences, Nucleic Acid
• Superoxide Dismutase
• Transcriptional Activation