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Article

Importance of the unique cationic residues arginine 12 and lysine 49 in the activity of the cardiotonic polypeptide anthopleurin B.

The Journal of biological chemistry - 7 Jan 1994

Gallagher M J, Blumenthal K M

Abstract excerpt

Sea anemone toxins are potentially important tools for understanding the pharmacology of voltage-sensitive sodium channels. We have previously described a bacterial expression system capable of producing large amounts of one such toxin, anthopleurin B (ApB), which delays channel repolarization (Gallagher, M. J., and Blumenthal K. M. (1992) J. Biol. Chem. 267, 13958-13963). It has been suggested that cationic...

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PMID: 8276803

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