Article
Importance of the unique cationic residues arginine 12 and lysine 49 in the activity of the cardiotonic polypeptide anthopleurin B.
The Journal of biological chemistry - 7 Jan 1994
Gallagher M J, Blumenthal K M
Abstract excerpt
Sea anemone toxins are potentially important tools for understanding the pharmacology of voltage-sensitive sodium channels. We have previously described a bacterial expression system capable of producing large amounts of one such toxin, anthopleurin B (ApB), which delays channel repolarization (G...
Topics
- Amino Acid Sequence
- Animals
- Arginine
- Base Sequence
- DNA Primers
- Intercellular Signaling Peptides and Proteins
- Lysine
- Mice
- Molecular Sequence Data
- Mutation
- Peptides
- Sea Anemones
- Sequence Homology, Amino Acid
- Tumor Cells, Cultured