Article
Phenotypic change of endothelin receptor subtype in cultured rat vascular smooth muscle cells.
Endocrinology - 1 Jan 1994
Eguchi S, Hirata Y, Imai T, Kanno K, Marumo F
Abstract excerpt
An endothelium-derived vasoactive peptide, endothelin (ET)-1, is a potent constrictor and mitogen for vascular smooth muscle cells (VSMC). To determine whether vascular ET receptor subtypes phenotypically change during in vitro culture conditions, we studied the expression of ET receptor subtypes, ET-induced phosphoinositide breakdown, and DNA synthesis in cultured rat VSMCs during serial passages. Binding...
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