Article
The MHC influences acute graft versus host disease in MHC matched adults undergoing allogeneic bone marrow transplantation.
Bone marrow transplantation - 1 Oct 1993
Smyth L A, Witt C S, Christiansen F T, Herrmann R P, Hollingsworth P N, Townend D C, Edward E, Dawkins R L
Abstract excerpt
To determine whether the MHC plays an antigen non-specific role in the development of acute GVHD, the prevalence of acute GVHD in relation to MHC genotype was examined in 51 adult patients undergoing allogeneic BM grafting. The majority of patients received grafts from HLA-identical siblings. HLA-B7 haplotypes were associated with a decreased risk of acute GVHD (2 of 15, p = 0.005) whereas HLA-B44 haplotypes were...
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