Article
Genetics of allogeneic hematopoietic cell transplantation. Role of HLA matching, functional variation in immune response genes.
Immunologic research - 1 Jan 2008
Hansen John A, Petersdorf Effie W, Lin Ming-Tseh, Wang Steven, Chien Jason W, Storer Barry, Martin Paul J
Abstract excerpt
Successful outcome following hematopoietic stem cell transplantation (HSCT) is ultimately determined by the ability to achieve sustained engraftment and immune reconstitution, control of graft-versus-host disease (GVHD), and in patients with hematological malignancy the complete eradication of abnormal or malignant cells. GVHD, which can be a serious and fatal complication, is an immune reaction that is initiated...
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