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Article

LMP7 polymorphism may modify the presentation and clinical impact of minor histocompatibility antigens in matched related hematopoietic stem cell transplantation.

Cellular immunology - 1 Jun 2021

Mossallam Ghada I, Fattah Raafat Abdel, Bokhary Mahmoud, Moneer Manar, Mahmoud Hossam K

Abstract excerpt

Differential expression of minor histocompatibility antigens between the recipient and donor determines their disparity and can be modified by immunoproteasomes that regulate their processing and presentation. We examined the impact of HA-1 and HA-8 disparity, and immunoproteasome LMP7 polymorphism in 130 pairs. In multivariate analysis, HA-1 disparity showed a statistically significant association with an...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33798908
DOI: 10.1016/j.cellimm.2021.104329

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