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Article

The U1‐snRNP complex: structural properties relating to autoimmune pathogenesis in rheumatic diseases

23 Dec 2009

Abstract excerpt

The U1 small nuclear ribonucleoprotein particle (snRNP) is a target of autoreactive B cells and T cells in several rheumatic diseases including systemic lupus erythematosus (SLE) and mixed connective tissue disease (MCTD). We propose that inherent structural properties of this autoantigen complex, including common RNA-binding motifs, B and T-cell epitopes, and a unique stimulatory RNA molecule, underlie its...

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PMID: 20192997
DOI: 10.1111/j.0105-2896.2009.00863.x

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