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Article

B cell epitope on the U1 snRNP-C autoantigen contains a sequence similar to that of the herpes simplex virus protein.

European journal of immunology - 1 May 1993

Misaki Y, Yamamoto K, Yanagi K, Miura H, Ichijo H, Kato T, Mato T, Welling-Wester S, Nishioka K, Ito K

Abstract excerpt

The mechanism of autoantibody production in autoimmune diseases is not well understood. In the present study we performed the B cell epitope mapping of the U1 small nuclear ribonucleoprotein (snRNP)-C, one of the target molecules of anti-nRNP autoantibody to investigate how B cells respond to the autoantigen. After cloning and expression of a full length complementary DNA (cDNA) encoding the U1-C protein, several...

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PMID: 7682956
DOI: 10.1002/eji.1830230513

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