Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

B cell epitope on the U1 snRNP-C autoantigen contains a sequence similar to that of the herpes simplex virus protein.

European journal of immunology - 1 May 1993

Misaki Y, Yamamoto K, Yanagi K, Miura H, Ichijo H, Kato T, Mato T, Welling-Wester S, Nishioka K, Ito K

Abstract excerpt

The mechanism of autoantibody production in autoimmune diseases is not well understood. In the present study we performed the B cell epitope mapping of the U1 small nuclear ribonucleoprotein (snRNP)-C, one of the target molecules of anti-nRNP autoantibody to investigate how B cells respond to the autoantigen. After cloning and expression of a full length complementary DNA (cDNA) encoding the U1-C protein, several...

Topics

Amino Acid Sequence
Autoantigens
B-Lymphocytes
Cloning, Molecular
Cross Reactions
Epitopes
Humans
Immediate-Early Proteins
Molecular Sequence Data
Mutation
Ribonucleoprotein, U1 Small Nuclear

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Ribonucleoproteins, Small Nuclear

Simplexvirus

Viral Regulatory and Accessory Proteins

snRNP Core Proteins

Source

Identifiers

PMID: 7682956
DOI: 10.1002/eji.1830230513

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7682956-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

B cell epitope on the U1 snRNP-C autoantigen contains a sequence similar to that of the herpes simplex virus protein.PMID 7682956Read ↗

Distinctive immune response patterns of human and murine autoimmune sera to U1 small nuclear ribonucleoprotein C protein.Semantic proximity Read ↗

The U1‐snRNP complex: structural properties relating to autoimmune pathogenesis in rheumatic diseasesSemantic proximity Read ↗

B cells process and present lupus autoantigens that initiate autoimmune T cell responses.Semantic proximity Read ↗

Autoantibodies to the A/B Proteins of the Heterogeneous Nuclear Ribonucleoprotein Complex: Novel Tools for the Diagnosis of Rheumatic DiseasesSemantic proximity Read ↗

Major histocompatibility complex class II gene associations with anti-U1 small nuclear ribonucleoprotein antibody. Relationship to immunoreactivity with individual constituent proteins.Semantic proximity Read ↗

Epitope patterns of anti-RNP antibodies in rheumatic diseases. Evidence for an antigen-driven autoimmune response.Semantic proximity Read ↗

Autoantigens of Nervous System and Human Coronavirus Antigens: Is There a Possibility for Molecular Mimicry?Semantic proximity Read ↗

Hepatitis B virus and Homo sapiens proteomewide analysis: A profusion of viral peptide overlaps in neuron-specific human proteinsSemantic proximity Read ↗

Key residues revealed in a major conformational epitope of the U1-70K protein.Semantic proximity Read ↗

Role of intermolecular/intrastructural B- and T-cell determinants in the diversification of autoantibodies to ribonucleoprotein particles.Semantic proximity Read ↗

Autoantibodies to the Nuclear Sp100 Protein in Primary Biliary Cirrhosis and Associated Diseases: Epitope Specificity and Immunoglobulin Class DistributionSemantic proximity Read ↗

MHC class II gene associations with autoantibodies to U1A and SmD1 proteins.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.