Single point mutations in domain II of the yeast mitochondrial release factor mRF-1 affect ribosome binding.

doi:10.1093/nar/21.23.5308

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Article

Single point mutations in domain II of the yeast mitochondrial release factor mRF-1 affect ribosome binding.

Nucleic acids research - 25 Nov 1993

Pel H J, Rep M, Dubbink H J, Grivell L A

Abstract excerpt

We have recently described two yeast strains that are mutated in the MRF1 gene encoding the mitochondrial release factor mRF-1. Both mutants provoke gene-specific defects in mitochondrial translational termination. In the present study we report the cloning, sequencing, as well as an analysis of...

Topics

Alleles
Amino Acid Sequence
Base Sequence
Cloning, Molecular
DNA Primers
Fungal Proteins
Mitochondria
Mitochondrial Proteins
Molecular Sequence Data
Peptide Chain Termination, Translational
Point Mutation
Recombinant Fusion Proteins
Ribosomes
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins
Sequence Alignment
Sequence Homology, Amino Acid
Structure-Activity Relationship

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Identifiers

PMID: 8265342
DOI: 10.1093/nar/21.23.5308
PMCID: PMC310563

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8265342-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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