In vitro activity of penciclovir against clinical isolates of acyclovir-resistant and foscarnet-resistant herpes simplex virus.

doi:10.1128/AAC.37.10.2241

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Article

In vitro activity of penciclovir against clinical isolates of acyclovir-resistant and foscarnet-resistant herpes simplex virus.

Antimicrobial agents and chemotherapy - 1 Oct 1993

Safrin S, Phan L

Abstract excerpt

We tested 23 clinical isolates of acyclovir-susceptible, acyclovir-resistant, and foscarnet-resistant herpes simplex virus for susceptibility to penciclovir. Isolates showed cross-resistance to penciclovir and acyclovir, but penciclovir retained a relative activity against foscarnet-resistant iso...

Topics

Acyclovir
Antiviral Agents
DNA-Directed DNA Polymerase
Drug Resistance, Microbial
Foscarnet
Guanine
Half-Life
Humans
Microbial Sensitivity Tests
Mutation
Simplexvirus
Thymidine Kinase

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