Increased virulence of a mouse-adapted variant of influenza A/FM/1/47 virus is controlled by mutations in genome segments 4, 5, 7, and 8.

doi:10.1128/JVI.64.9.4523-4533.1990

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Article

Increased virulence of a mouse-adapted variant of influenza A/FM/1/47 virus is controlled by mutations in genome segments 4, 5, 7, and 8.

Journal of virology - 1 Sept 1990

Brown E G

Abstract excerpt

To cause disease, influenza virus must possess several genetically determined abilities that mediate stages in pathogenesis. The virulent mouse-adapted variant A/FM/1/47-MA (FM-MA), derived from the avirulent A/FM/1/47 (FM) strain, had acquired mutations in genes that control virulence. The purpo...

Topics

Animals
Cell Line
Crosses, Genetic
Genes, Viral
Genetic Variation
Genotype
Influenza A virus
Mice
Mutation
Nucleotide Mapping
RNA, Viral
Ribonuclease T1
Viral Plaque Assay
Viral Proteins
Virulence

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