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Article

Rapid decline of chronic myeloid leukemic cells in long-term culture due to a defect at the leukemic stem cell level.

1 Jul 1992

Abstract excerpt

In this report we describe a quantitative in vitro assay for the most primitive type of leukemic precursors yet defined in patients with chronic myeloid leukemia (CML). This assay is based on the recently described "long-term culture-initiating cell" (LTC-IC) assay for primitive normal human hematopoietic cells. Such cells, when cocultured with competent fibroblast feeder layers, give rise after a minimum of 5...

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PMID: 1631107
DOI: 10.1073/pnas.89.13.6192

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Rapid decline of chronic myeloid leukemic cells in long-term culture due to a defect at the leukemic stem cell level.PMID 1631107Read ↗

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