Article
Two-locus mitochondrial and nuclear gene models for mitochondrial disorders.
Genetic epidemiology - 1 Jan 1992
Bu X, Yang H Y, Shohat M, Rotter J I
Abstract excerpt
Stimulated by a large pedigree with a cochlear form of deafness, for which we considered a two-locus mitochondrial and nuclear gene model, we have extended the classic methods of segregation analysis to these classes of two-locus disorders. Based on the unique maternal transmission pattern of the mitochondria, we demonstrate that utilization of the maternal line pedigree allows us to simplify the various...
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