Article
Two-locus mitochondrial and nuclear gene models for mitochondrial disorders.
Genetic epidemiology - 1 Jan 1992
Bu X, Yang H Y, Shohat M, Rotter J I
Abstract excerpt
Stimulated by a large pedigree with a cochlear form of deafness, for which we considered a two-locus mitochondrial and nuclear gene model, we have extended the classic methods of segregation analysis to these classes of two-locus disorders. Based on the unique maternal transmission pattern of the...
Topics
- Cell Nucleus
- Chromosome Mapping
- DNA, Mitochondrial
- Gene Frequency
- Genes, Dominant
- Genetic Diseases, Inborn
- Genetic Linkage
- Humans
- Meiosis
- Models, Genetic
- Models, Statistical
- Mutation
- Phenotype