Article
Does accounting for mitochondrial genetic variation improve the fit of genetic models?
Genetic epidemiology - 1 Jan 2001
Czerwinski S A, Williams J T, Demerath E W, Towne B, Siervogel R M, Blangero J
Abstract excerpt
We describe a simple variance component model for estimating the effect of mitochondrial DNA (mtDNA) inheritance on quantitative trait variation. The model is applied to quantitative trait Q5 in the simulated general population data from Genetic Analysis Workshop (GAW) 12. Although the mitochondrial effect on Q5 is small (5.3%) and the power of the method to detect the effect is correspondingly low, analysis over...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.