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Article

Loricrin and human skin diseases: molecular basis of loricrin keratodermas.

Histology and histopathology - 1 Jul 1998

Ishida-Yamamoto A, Takahashi H, Iizuka H

Abstract excerpt

The cornified cell envelope (CE) is a tough structure formed beneath the plasma membrane of terminally differentiated keratinocytes. Recent progress in understanding the molecular organization of the CE has disclosed the complex, yet orderly structure that functions as a protective barrier against the environment. We have recently demonstrated that two inherited skin diseases, Vohwinkel's syndrome (VS) and...

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PMID: 9690138
DOI: 10.14670/HH-13.819

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Related research

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Research trail→

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Loricrin and human skin diseases: molecular basis of loricrin keratodermas.PMID 9690138Read ↗

Loricrin keratoderma: a novel disease entity characterized by nuclear accumulation of mutant loricrin.Semantic proximity Read ↗

A molecular defect in loricrin, the major component of the cornified cell envelope, underlies Vohwinkel's syndrome.Semantic proximity Read ↗

Loricrin mutation in Vohwinkel's keratoderma is unique to the variant with ichthyosis.Semantic proximity Read ↗

Loricrin: Past, Present, and FutureSemantic proximity Read ↗

Transgenic mice expressing a mutant form of loricrin reveal the molecular basis of the skin diseases, Vohwinkel syndrome and progressive symmetric erythrokeratoderma.Semantic proximity Read ↗

Abnormal cornified cell envelope formation in mutilating palmoplantar keratoderma unrelated to epidermal differentiation complex.Semantic proximity Read ↗

Loricrin at the Boundary between Inside and OutsideSemantic proximity Read ↗

Structural and functional consequences of loricrin mutations in human loricrin keratoderma (Vohwinkel syndrome with ichthyosis).Semantic proximity Read ↗

A novel insertional mutation in loricrin in Vohwinkel's Keratoderma.Semantic proximity Read ↗

A recurrent mutation in the loricrin gene underlies the ichthyotic variant of Vohwinkel syndrome.Semantic proximity Read ↗

A novel c.545-546insG mutation in the loricrin gene correlates with a heterogeneous phenotype of loricrin keratoderma.Semantic proximity Read ↗

Loricrin downregulation and epithelial-related disorders: a systematic review.Semantic proximity Read ↗

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