Article
Activation of vascular endothelial growth factor receptor 2 in a cellular model of loricrin keratoderma.
The Journal of biological chemistry - 21 May 2010
Yoneda Kozo, Demitsu Toshio, Nakai Kozo, Moriue Tetsuya, Ogawa Wataru, Igarashi Junsuke, Kosaka Hiroaki, Kubota Yasuo
Abstract excerpt
Loricrin is a major constituent of the epidermal cornified cell envelope. Recently, heterozygous loricrin gene mutations have been identified in two dominantly inherited skin diseases, Vohwinkel syndrome with ichthyosis and progressive symmetric erythrokeratoderma, collectively termed loricrin keratoderma. We generated stable HaCaT cell lines that express wild-type (WT) loricrin and a mutant form found in...
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