Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Expression of wild-type, but not mutant, loricrin causes programmed cell death in HaCaT keratinocytes.

The Journal of dermatology - 1 Nov 2010

Yoneda Kozo, Demitsu Toshio, Manabe Motomu, Igarashi Junsuke, Kosaka Hiroaki, Inagaki Nobuya, Takahashi Hidetoshi, Kon Atsushi, Kakurai Maki, Kubota Yasuo

Abstract excerpt

The epidermal cornified cell envelope is a complex protein-lipid composite that replaces the plasma membrane of corneocytes and is crucial for epidermal barrier function. Loricrin is a major constituent of the epidermal cornified cell envelope, contributing approximately 70% by mass. In order to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis
Share to Cell Line
Share to Enzyme Activation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epidermis

Share to Gene Expression

Share to Keratinocytes

Share to Membrane Proteins

Share to Transfection

Source

Identifiers

PMID: 21039784
DOI: 10.1111/j.1346-8138.2010.00932.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21039784-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expression of wild-type, but not mutant, loricrin causes programmed cell death in HaCaT keratinocytes.PMID 21039784Read ↗

Loricrin and human skin diseases: molecular basis of loricrin keratodermas.Semantic proximity Read ↗

Premature apoptosis of keratinocytes and the dysregulation of keratinization in porokeratosisSemantic proximity Read ↗

Activation of vascular endothelial growth factor receptor 2 in a cellular model of loricrin keratoderma.Semantic proximity Read ↗

Loricrin: Past, Present, and FutureSemantic proximity Read ↗

The cornified envelope: a model of cell death in the skin.Semantic proximity Read ↗

HaCaT Keratinocytes and Primary Epidermal Keratinocytes Have Different Transcriptional Profiles of Cornified Envelope-Associated Genes to T Helper Cell CytokinesSemantic proximity Read ↗

Loricrin downregulation and epithelial-related disorders: a systematic review.Semantic proximity Read ↗

The cornified envelope: a model of cell death in the skinSemantic proximity Read ↗

Overexpression of human loricrin in transgenic mice produces a normal phenotype.Semantic proximity Read ↗

The c.323 G>C mutation in LORICRIN causes new-found late-onset autosomal dominant loricrin keratoderma in a Chinese Han Pedigree.Semantic proximity Read ↗

Identification of immature cornified envelopes in the barrier‐impaired epidermis by characterization of their hydrophobicity and antigenicities of the componentsSemantic proximity Read ↗

Loricrin keratoderma: a novel disease entity characterized by nuclear accumulation of mutant loricrin.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.