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Article

Differential gene expression in response to transforming growth factor‐β1 by fetal and postnatal dermal fibroblasts

1 Nov 2007

Abstract excerpt

The multipotent growth factor transforming growth factor (TGF)-beta1 is consistently linked with fibrosis and scarring. The perfect (scarless) healing of cutaneous wounds in early gestational age fetuses is proposed to be due to this tissue's predominance of the TGF-beta3 isoform over the profibrotic TGF-beta1 and 2. Nevertheless, TGF-beta1 is present during wound healing in the early fetus and recently we...

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Identifiers

PMID: 18028139
DOI: 10.1111/j.1524-475x.2007.00314.x

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