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Article

Calmodulin-dependent protein kinase II mediates inactivation of MPF and CSF upon fertilization of Xenopus eggs.

Nature - 18 Nov 1993

Lorca T, Cruzalegui F H, Fesquet D, Cavadore J C, Méry J, Means A, Dorée M

Abstract excerpt

In vertebrates, unfertilized eggs are arrested at second meiotic metaphase by a cytostatic factor (CSF), an essential component of which is the product of the c-mos proto-oncogene. CSF prevents ubiquitin-dependent degradation of mitotic cyclins and thus inactivation or the M phase-promoting factor (MPF). Fertilization or parthenogenetic activation triggers a transient increase in the cytoplasmic free Ca2+...

Topics

Amino Acid Sequence
Animals
CDC2 Protein Kinase
Calcium
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Calcium-Calmodulin-Dependent Protein Kinases
Cells, Cultured
Cloning, Molecular
Cyclins
Enzyme Activation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Fertilization

Maturation-Promoting Factor

Molecular Sequence Data

Mutation

Myosin-Light-Chain Kinase

Peptide Fragments

Proto-Oncogene Proteins c-mos

Rats

Source

Identifiers

PMID: 8232587
DOI: 10.1038/366270a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8232587-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Calmodulin-dependent protein kinase II mediates inactivation of MPF and CSF upon fertilization of Xenopus eggs.PMID 8232587Read ↗

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