Article
Full-term mouse development by abolishing Zn2+-dependent metaphase II arrest without Ca2+ release
30 Jun 2010
Abstract excerpt
In vertebrates, a rise in intracellular free Ca(2+) (Ca(2+)(i)) levels during fertilization initiates second metaphase (mII) exit and the developmental programme. The Ca(2+) rise has long been considered to be crucial for development, but verifying this contribution would benefit from defining its role during fertilization. Here, we delineate the role of Ca(2+) release during mII exit in wild-type mouse eggs and...
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