Article
The vestigial locus of Drosophila melanogaster is involved in resistance to inhibitors of dTMP synthesis.
Molecular & general genetics : MGG - 1 Oct 1993
Silber J, Le Menn A, Chevillard S, Zider A, Paumard S
Abstract excerpt
The vestigal (vg) gene encodes a nuclear protein which plays a major role in the formation of the wing of Drosophila. Resistance or sensitivity to aminopterin, an inhibitor of the dihydrofolate reductase enzyme in D. melanogaster, seems to be associated with a specific alteration in vg gene funct...
Topics
- Aminopterin
- Animals
- Drosophila melanogaster
- Drug Resistance
- Floxuridine
- Folic Acid Antagonists
- Heterozygote
- Methotrexate
- Mutation
- Nuclear Proteins
- Phenotype
- Species Specificity