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Article

The vestigial locus of Drosophila melanogaster is involved in resistance to inhibitors of dTMP synthesis.

Molecular & general genetics : MGG - 1 Oct 1993

Silber J, Le Menn A, Chevillard S, Zider A, Paumard S

Abstract excerpt

The vestigal (vg) gene encodes a nuclear protein which plays a major role in the formation of the wing of Drosophila. Resistance or sensitivity to aminopterin, an inhibitor of the dihydrofolate reductase enzyme in D. melanogaster, seems to be associated with a specific alteration in vg gene function. Wild-type and vg mutant strains selected for growth on increasing concentrations of aminopterin display changes in...

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PMID: 8232210
DOI: 10.1007/BF00280199

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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The vestigial locus of Drosophila melanogaster is involved in resistance to inhibitors of dTMP synthesis.PMID 8232210Read ↗

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Drosophila dihydrofolate reductase mutations confer antifolate resistance to mammalian cells.Semantic proximity Read ↗

Truncated products of the vestigial proliferation gene induce apoptosis.Semantic proximity Read ↗

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Restoration of mutationally suppressed characters in Drosophila melanogaster.Semantic proximity Read ↗

A P element chimera containing captured genomic sequences was recovered at the vestigial locus in Drosophila following targeted transposition.Semantic proximity Read ↗

Comparative analysis of genetic toxicity of antiretroviral combinations in somatic cells of Drosophila melanogaster.Semantic proximity Read ↗

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The effect of dominant vestigial alleles upon vestigial-mediated wing patterning during development of Drosophila melanogaster.Semantic proximity Read ↗

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