vestigial suppressor genes and resistance to aminopterin in Drosophila melanogaster.

doi:10.1038/hdy.1992.152

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Article

vestigial suppressor genes and resistance to aminopterin in Drosophila melanogaster.

Heredity - 1 Nov 1992

Bazin C, Silber J

Abstract excerpt

We have shown that the vestigial (vg) mutant of D. melanogaster has a perturbed nucleotide metabolism compared to various wild-type strains. The mutant is particularly spontaneously resistant to aminopterin. The resistance seems to correlate with an increase in dihydrofolate reductase (DHFR) acti...

Topics

Aminopterin
Animals
Drosophila melanogaster
Drug Resistance
Female
Genes, Suppressor
Hypoxanthine Phosphoribosyltransferase
Male
Mutagenesis
Nucleotides
Phenotype
Tetrahydrofolate Dehydrogenase
Thymidine Kinase

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