Isolation and structural elucidation of tetracenomycin F2 and tetracenomycin F1: early intermediates in the biosynthesis of tetracenomycin C in Streptomyces glaucescens.

doi:10.1021/np50098a013

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Article

Isolation and structural elucidation of tetracenomycin F2 and tetracenomycin F1: early intermediates in the biosynthesis of tetracenomycin C in Streptomyces glaucescens.

Journal of natural products - 1 Aug 1993

Shen B, Nakayama H, Hutchinson C R

Abstract excerpt

This report describes the fermentation, isolation, and structural elucidation of tetracenomycin (Tcm) F2 [2], a metabolite produced by a blocked mutant strain WMH1092 of the Tcm C [1] producer Streptomyces glaucescens and by the recombinant strain S. glaucescens WMH1077 (pWHM722). Elucidation of...

Topics

Anthracenes
Anti-Bacterial Agents
Cyclization
Fermentation
Magnetic Resonance Spectroscopy
Mutation
Naphthacenes
Recombination, Genetic
Streptomyces

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