Article
Lack of T cell dysfunction and programmed cell death in human immunodeficiency virus type 1-infected chimpanzees correlates with absence of monocytotropic variants.
The Journal of infectious diseases - 1 Nov 1993
Schuitemaker H, Meyaard L, Kootstra N A, Dubbes R, Otto S A, Tersmette M, Heeney J L, Miedema F
Abstract excerpt
In asymptomatic human immunodeficiency virus (HIV) infection in humans, disturbed T cell functions such as anergy and programmed cell death, thought to result from inappropriate signaling by antigen-presenting cells due to HIV infection, precede increase in virus load, decline in CD4+ T cell numb...
Topics
- Amino Acid Sequence
- Animals
- Antigen-Presenting Cells
- Apoptosis
- Base Sequence
- CD4 Antigens
- Female
- Genetic Variation
- HIV Infections
- HIV-1
- Leukocytes, Mononuclear
- Male
- Molecular Sequence Data
- Pan troglodytes
- Sequence Homology, Amino Acid