Article
Monocytotropic human immunodeficiency virus type 1 (HIV-1) variants detectable in all stages of HIV-1 infection lack T-cell line tropism and syncytium-inducing ability in primary T-cell culture.
Journal of virology - 1 Jan 1991
Schuitemaker H, Kootstra N A, de Goede R E, de Wolf F, Miedema F, Tersmette M
Abstract excerpt
We previously demonstrated a correlation between the presence of syncytium-inducing (SI) human immunodeficiency virus type 1 (HIV-1) variants showing tropism for cell line H9 and the occurrence of rapid CD4 cell decline and progression to AIDS. In contrast, in stable asymptomatic individuals, we detected only isolates with low replication rates that were non-syncytium-inducing (NSI) and nontropic for the H9 cell...
Topics
- Acquired Immunodeficiency Syndrome
- CD4 Antigens
- Cell Line
- Cells, Cultured
- DNA Replication
- Genetic Variation
- Granulocyte-Macrophage Colony-Stimulating Factor
- HIV Seropositivity
- HIV-1
- Humans