Article
Down-modulation of epidermal growth factor receptor accompanies TNF-induced differentiation of the DiFi human adenocarcinoma cell line toward a goblet-like phenotype.
Journal of cellular physiology - 1 Nov 1993
Novotny-Smith C L, Zorbas M A, Mcisaac A M, Irimura T, Boman B M, Yeoman L C, Gallick G E
Abstract excerpt
Although the biologic response modifier tumor necrosis factor-alpha (TNF) is a known differentiation inducer in hematopoietic cells, its role in differentiation of other tissue types has yet to be elucidated. In the studies presented here, TNF treatment of the human rectal adenocarcinoma cell lin...
Topics
- Adenocarcinoma
- Blotting, Northern
- Cell Division
- Cell Transformation, Neoplastic
- Down-Regulation
- ErbB Receptors
- Humans
- Iodine Radioisotopes
- Membrane Glycoproteins
- Mucin-1
- Mucins
- Phenotype
- Precipitin Tests
- Rectal Neoplasms
- Time Factors