Article
The accumulation of five antibacterial agents in porin-deficient mutants of Escherichia coli.
The Journal of antimicrobial chemotherapy - 1 Aug 1993
Mortimer P G, Piddock L J
Abstract excerpt
A library of isogenic mutants containing Mud9-induced deletions of the structural and regulatory genes for the porin proteins OmpF and OmpC of Escherichia coli was constructed. The accumulation of norfloxacin, tetracycline, chloramphenicol, cephalothin and cefoxitin was measured with each strain, and shown to be reproducible with low experimental standard deviations, such that the roles of OmpF, OmpC and PhoE in...
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