The accumulation of five antibacterial agents in porin-deficient mutants of Escherichia coli.

doi:10.1093/jac/32.2.195

Back to search

Article

The accumulation of five antibacterial agents in porin-deficient mutants of Escherichia coli.

The Journal of antimicrobial chemotherapy - 1 Aug 1993

Mortimer P G, Piddock L J

Abstract excerpt

A library of isogenic mutants containing Mud9-induced deletions of the structural and regulatory genes for the porin proteins OmpF and OmpC of Escherichia coli was constructed. The accumulation of norfloxacin, tetracycline, chloramphenicol, cephalothin and cefoxitin was measured with each strain,...

Topics

Anti-Infective Agents
Cefoxitin
Cephalosporins
Chloramphenicol
Escherichia coli
Microbial Sensitivity Tests
Mutation
Norfloxacin
Phenotype
Porins
Tetracycline

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.