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Article

Exclusion of APC and MCC as the gene defect in one family with familial juvenile polyposis.

Gastroenterology - 1 Nov 1993

Leggett B A, Thomas L R, Knight N, Healey S, Chenevix-Trench G, Searle J

Abstract excerpt

BACKGROUND: In familial juvenile polyposis, multiple juvenile polyps occur throughout the colon. The genetic defect has not been characterized. The risk of colon cancer is increased, although the magnitude of the increased risk is controversial. The hypothesis of this study was that the genetic defect is within a tumor suppressor gene, possibly one already known to be inactivated in colorectal neoplasia. METHODS:...

Topics

Adenomatous Polyposis Coli
Adult
Child
Colorectal Neoplasms
Genes, APC
Genes, MCC
Genetic Linkage
Humans
Jejunal Neoplasms
Middle Aged
Mutation
Pedigree

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 8224634
DOI: 10.1016/0016-5085(93)90134-x

Genes

APC
MCC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8224634-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Click a neighbor to travelStep 1 · 12 closest

Exclusion of APC and MCC as the gene defect in one family with familial juvenile polyposis.PMID 8224634Read ↗

Mutations in DPC4 (SMAD4) cause juvenile polyposis syndrome, but only account for a minority of cases.Semantic proximity Read ↗

Familial juvenile polyposis coli with APC gene mutation.Semantic proximity Read ↗

Exclusion of the APC gene as the cause of a variant form of familial adenomatous polyposis (FAP)Semantic proximity Read ↗

Mutations of the adenomatous polyposis coli gene in familial polyposis coli patients and sporadic colorectal tumors.Semantic proximity Read ↗

A family with juvenile polyposis linked to the BMPR1A locus: cryptic mutation or closely linked gene?Semantic proximity Read ↗

Symptomatic colonic polyps in childhood: not so benign.Semantic proximity Read ↗

Analysis of genetic and phenotypic heterogeneity in juvenile polyposis.Semantic proximity Read ↗

Low prevalence of loss of heterozygosity and SMAD4 mutations in sporadic and familial juvenile polyposis syndrome-associated juvenile polyps.Semantic proximity Read ↗

Report of a family segregating mutations in both the APC and MSH2 genes: juvenile onset of colorectal cancer in a double heterozygote.Semantic proximity Read ↗

Allele loss in colorectal cancer at the Cowden disease/juvenile polyposis locus on 10q.Semantic proximity Read ↗

Linkage of a variant or attenuated form of adenomatous polyposis coli to the adenomatous polyposis coli (APC) locus.Semantic proximity Read ↗

Large genomic deletions of SMAD4, BMPR1A and PTEN in juvenile polyposis.Semantic proximity Read ↗

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