Article
Low prevalence of loss of heterozygosity and SMAD4 mutations in sporadic and familial juvenile polyposis syndrome-associated juvenile polyps.
The American journal of gastroenterology - 1 Oct 2004
Fogt Franz, Brown Charlotte A, Badizadegan Kamrari, Zimmerman Robert L, Odze Robert
Abstract excerpt
BACKGROUND: Juvenile polyps (JP) may develop sporadically or may be associated with the familial juvenile polyposis syndrome (FJPS). In FJPS, the epithelium is susceptible to dysplasia and, ultimately adenocarcinoma. However, the mechanisms involved in this transformation are unknown. Since the epithelium in colorectal carcinogenesis undergoes a stepwise genetic progression, the purpose of this study was to...
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