Detection of the hepatitis B virus major pre-core mutation by the amplification refractory mutation system technique.

doi:10.1016/s0923-2516(06)80046-4

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Article

Detection of the hepatitis B virus major pre-core mutation by the amplification refractory mutation system technique.

Research in virology - 1 Jan 2000

Gramegna M, Lampertico P, Lobbiani A, Colucci G

Abstract excerpt

HBeAg/anti-HBe seroconversion is associated, in some patients affected by type B chronic active hepatitis (CAH), with the occurrence of HBV pre-core mutants characterized by a common G-A change at codon 83. Since this mutation has important clinical correlations, we tried to develop a fast and re...

Topics

Base Sequence
Codon
Hepatitis B
Hepatitis B Core Antigens
Hepatitis B virus
Hepatitis, Chronic
Humans
Molecular Sequence Data
Mutation
Polymerase Chain Reaction
Protein Precursors
Viral Core Proteins

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