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Article

Linking of mPGES-1 and iNOS activates stem-like phenotype in EGFR-driven epithelial tumor cells.

Nitric oxide : biology and chemistry - 1 Jun 2017

Terzuoli Erika, Finetti Federica, Costanza Filomena, Giachetti Antonio, Ziche Marina, Donnini Sandra

Abstract excerpt

Inflammatory prostaglandin E-2 (PGE-2) favors cancer progression in epithelial tumors characterized by persistent oncogene input. However, its effects on tumor cell stemness are poorly understood at molecular level. Here we describe two epithelial tumor cells A431 and A459, originating from human lung and skin tumors, in which epithelial growth factor (EGF) induces sequential up-regulation of mPGES-1 and iNOS...

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Topics

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Share to Cell Line, Tumor
Share to Epithelial Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epithelial-Mesenchymal Transition

Share to ErbB Receptors

Share to Nitric Oxide Synthase Type II

Share to Spheroids, Cellular

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Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 28257996
DOI: 10.1016/j.niox.2017.02.010

Genes

EGF
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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