Expansion of a B-lymphocyte clone producing IgM auto-antibodies encoded by a somatically mutated VHI gene in the spleen of an autoimmune patient.

doi:10.1007/BF00390266

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Article

Expansion of a B-lymphocyte clone producing IgM auto-antibodies encoded by a somatically mutated VHI gene in the spleen of an autoimmune patient.

Rheumatology international - 1 Jan 1994

Jahn S, Niemann B, Winkler T, Kalden J R, von Baehr R

Abstract excerpt

Seventy-six human B-cell hybridomas were obtained by fusing B lymphocytes from the spleen of a patient with chronic idiopathic thrombocytopenia (ITP). Two independent hybridoma clones producing IgM autoantibodies reacting with platelets and other antigens from both the internal and the external environments were established from this fusion experiment. The IgM autoantibodies produced by the two hybridoma clones...

Topics

Adolescent
Animals
Autoantibodies
Autoimmune Diseases
B-Lymphocytes
Base Sequence
Clone Cells
Female
Genes, Immunoglobulin
Humans
Hybridomas

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunoglobulin M

Mice

Molecular Sequence Data

Mutation

Spleen

Thrombocytopenia

Source

Open in PubMed

Identifiers

PMID: 8202662
DOI: 10.1007/BF00390266

Genes

CDR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8202662-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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