Genomic structure, chromosomal localization, and conserved alternative splice forms of thrombopoietin

doi:10.1182/blood.v85.4.981.bloodjournal854981

Article

Genomic structure, chromosomal localization, and conserved alternative splice forms of thrombopoietin

15 Feb 1995

Abstract excerpt

Thrombopoietin (TPO), the ligand for c-mpl, is a novel cytokine comprising an amino terminal domain with homology to erythropoietin and a glycosylated carboxyl terminal domain that does not bear overall homology to other known proteins. We report the cloning of cDNAs encoding the porcine and murine TPO and the characterization of the human TPO gene. The cDNA for an additional splice form (TPO-2) with a...

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