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Article

Structures of three human beta alcohol dehydrogenase variants. Correlations with their functional differences.

Journal of molecular biology - 10 Jun 1994

Hurley T D, Bosron W F, Stone C L, Amzel L M

Abstract excerpt

The three-dimensional structures of three variants of human beta alcohol dehydrogenase have been determined to 2.5 A resolution. These three structures differ only in the amino acid at position 47 and the molecules occupying the alcohol binding site. Human beta 1 alcohol dehydrogenase has an Arg at position 47 and was crystallized in a complex with NAD(H) and cyclohexanol. A naturally occurring variant of beta 1...

Topics

Alcohol Dehydrogenase
Crystallization
Crystallography, X-Ray
Cyclohexanols
Genetic Variation
Humans
Hydrogen Bonding
Isoenzymes
Molecular Structure
Mutagenesis, Site-Directed
NAD

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Conformation

Pyrazoles

Recombinant Proteins

Sequence Alignment

Water

Source

Identifiers

PMID: 8201622
DOI: 10.1006/jmbi.1994.1382

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8201622-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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