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Article

Crystal structures of mouse class II alcohol dehydrogenase reveal determinants of substrate specificity and catalytic efficiency.

Journal of molecular biology - 15 Sept 2000

Svensson S, Höög J O, Schneider G, Sandalova T

Abstract excerpt

The structure of mouse class II alcohol dehydrogenase (ADH2) has been determined in a binary complex with the coenzyme NADH and in a ternary complex with both NADH and the inhibitor N-cyclohexylformamide to 2.2 A and 2.1 A resolution, respectively. The ADH2 dimer is asymmetric in the crystal with different orientations of the catalytic domains relative to the coenzyme-binding domains in the two subunits,...

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Identifiers

PMID: 10970744
DOI: 10.1006/jmbi.2000.4039

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