Human liver alcohol dehydrogenase: the unique properties of the "atypical" isoenzyme beta 2 beta 2-Bern can be explained by a single base mutation.

doi:10.1016/0741-8329(85)90014-x

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Article

Human liver alcohol dehydrogenase: the unique properties of the "atypical" isoenzyme beta 2 beta 2-Bern can be explained by a single base mutation.

Alcohol (Fayetteville, N.Y.) - 1 Jan 2000

Bühler R, Hempel J, Von Wartburg J P, Jörnvall H

Abstract excerpt

Two allelic variant alcohol dehydrogenase isoenzymes, beta 2 beta 2-Bern and beta 1 beta 1, coded by the ADH2 locus, were isolated from human livers of Caucasian origin. They represent the "atypical" and "typical" phenotype, respectively. beta 2 beta 2-Bern has a higher specific activity and a lo...

Topics

Alcohol Oxidoreductases
Amino Acid Sequence
Amino Acids
Humans
Isoenzymes
Liver
Mutation

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