Article
Genetic and physiological association of diabetes susceptibility with raised Na+/H+ exchange activity.
Proceedings of the National Academy of Sciences of the United States of America - 21 Jun 1994
Morahan G, McClive P, Huang D, Little P, Baxter A
Abstract excerpt
Insulin-dependent diabetes mellitus is a multigenic autoimmune disease, for which one of the best animal models is the nonobese diabetic (NOD) mouse strain. In both humans and NOD mice, major histocompatibility complex genes are implicated as risk factors in the disease process. Other susceptibil...
Topics
- Alleles
- Animals
- Chromosome Mapping
- Crosses, Genetic
- Diabetes Mellitus, Type 1
- Female
- Genetic Carrier Screening
- Genetic Markers
- Genetic Predisposition to Disease
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Inbred NOD
- Mice, Inbred Strains
- Polymorphism, Genetic
- Sodium-Hydrogen Exchangers