Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A human protein containing a "cold shock" domain binds specifically to H-DNA upstream from the human gamma-globin genes.

The Journal of biological chemistry - 13 May 1994

Horwitz E M, Maloney K A, Ley T J

Abstract excerpt

We previously determined that a region between positions -228 and -189 upstream from the human gamma-globin genes can form an intramolecular triplex (H-DNA) in supercoiled plasmids. To identify proteins that might interact with this DNA structure, we performed expression cloning using an adult bone marrow cDNA library and the single-stranded region of the H-DNA structure as a probe. We cloned molecules very...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Binding Sites
Share to DNA-Binding Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Molecular Sequence Data

Share to Mutation

Share to Plasmids

Share to Promoter Regions, Genetic

Share to Recombinant Proteins

Source

Identifiers

PMID: 8188694

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A human protein containing a "cold shock" domain binds specifically to H-DNA upstream from the human gamma-globin genes.PMID 8188694Read ↗

An intramolecular DNA triplex is disrupted by point mutations associated with hereditary persistence of fetal hemoglobin.Semantic proximity Read ↗

DHX9 helicase is involved in preventing genomic instability induced by alternatively structured DNA in human cells.Semantic proximity Read ↗

Somatic mutation and SNP in the promoter of dbpA and human hepatocarcinogenesis.Semantic proximity Read ↗

Y box-binding protein-1 binds preferentially to single-stranded nucleic acids and exhibits 3'-->5' exonuclease activity.Semantic proximity Read ↗

A large deletion in the human alpha-globin cluster caused by a replication error is associated with an unexpectedly mild phenotype.Semantic proximity Read ↗

Genomic structure of the human mitochondrial chaperonin genes: HSP60 and HSP10 are localised head to head on chromosome 2 separated by a bidirectional promoter.Semantic proximity Read ↗

Site-directed insertion of long single-stranded DNA fragments into plasmid DNA.Semantic proximity Read ↗

Mammalian Hsp70 and Hsp110 proteins bind to RNA motifs involved in mRNA stability.Semantic proximity Read ↗

The T----C substitution at -198 of the A gamma-globin gene associated with the British form of HPFH generates overlapping recognition sites for two DNA-binding proteins.Semantic proximity Read ↗

CDP/cut is the DNA-binding subunit of histone gene transcription factor HiNF-D: a mechanism for gene regulation at the G1/S phase cell cycle transition point independent of transcription factor E2F.Semantic proximity Read ↗

The genomic DNA phi Fd103 probe is sensitive marker for detection of human hypervariable genomic regions.Semantic proximity Read ↗

Structures of p63 DNA binding domain in complexes with half-site and with spacer-containing full response elementsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.