Article
Somatic mutation and SNP in the promoter of dbpA and human hepatocarcinogenesis.
International journal of oncology - 1 Oct 2002
Hayashi Junpei, Kajino Kazunori, Umeda Tomoyuki, Takano Seigo, Arakawa Yasuyuki, Kudo Masatoshi, Hino Okio
Abstract excerpt
Human DNA-binding protein (dbpA) is a member of a Y-box binding protein family containing a cold shock domain. The increased expression of Y box binding proteins in somatic cells is associated with cell proliferation and transformation. Recently, we isolated a splicing variant of dbpA as a candidate for the cellular recombinogenic protein that leads to genomic instability and inflammation-mediated...
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