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Article

Cloning and characterization of the SCS1 gene required for the expression of genes in yeast phospholipid synthesis.

Journal of biochemistry - 1 Jan 1994

Hosaka K, Nikawa J, Kodaki T, Yamashita S

Abstract excerpt

A dominant mutation of Saccharomyces cerevisiae, CSE1, caused a decrease in the expression of the INO1 gene product, inositol-1-phosphate synthase. The residual activity was completely repressed by the addition of choline to the medium. A mutant carrying this mutation could not grow in the presence of choline unless inositol was added to the medium. Here we report a suppressor gene of the CSE1 mutation, SCS1...

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Source

Identifiers

PMID: 8188619
DOI: 10.1093/oxfordjournals.jbchem.a124287

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Cloning and characterization of the SCS1 gene required for the expression of genes in yeast phospholipid synthesis.PMID 8188619Read ↗

A dominant mutation that alters the regulation of INO1 expression in Saccharomyces cerevisiae.Semantic proximity Read ↗

Cloning and sequence of the SCS2 gene, which can suppress the defect of INO1 expression in an inositol auxotrophic mutant of Saccharomyces cerevisiae.Semantic proximity Read ↗

Role of the yeast VAP homolog, Scs2p, in INO1 expression and phospholipid metabolism.Semantic proximity Read ↗

Genome expression analysis in yeast reveals novel transcriptional regulation by inositol and choline and new regulatory functions for Opi1p, Ino2p, and Ino4p.Semantic proximity Read ↗

Regulation of phospholipid biosynthesis by phosphatidylinositol transfer protein Sec14p and its homologues. A critical role for phosphatidic acid.Semantic proximity Read ↗

The role of phosphatidylcholine biosynthesis in the regulation of the INO1 gene of yeast.Semantic proximity Read ↗

Overproduction of the Opi1 repressor inhibits transcriptional activation of structural genes required for phospholipid biosynthesis in the yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

Interaction between repressor Opi1p and ER membrane protein Scs2p facilitates transit of phosphatidic acid from the ER to mitochondria and is essential for INO1 gene expression in the presence of choline.Semantic proximity Read ↗

Cloning and sequence of the SCS3 gene which is required for inositol prototrophy in Saccharomyces cerevisiae.Semantic proximity Read ↗

The OPI1 gene of Saccharomyces cerevisiae, a negative regulator of phospholipid biosynthesis, encodes a protein containing polyglutamine tracts and a leucine zipper.Semantic proximity Read ↗

Genome-wide screen for inositol auxotrophy in Saccharomyces cerevisiae implicates lipid metabolism in stress response signaling.Semantic proximity Read ↗

The stability of the Opi1p repressor for phospholipid biosynthetic gene expression in Saccharomyces cerevisiae is dependent on its interactions with Scs2p and Ino2p.Semantic proximity Read ↗

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