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Article

A dominant mutation that alters the regulation of INO1 expression in Saccharomyces cerevisiae.

Journal of biochemistry - 1 Mar 1992

Hosaka K, Nikawa J, Kodaki T, Yamashita S

Abstract excerpt

A dominant, single nuclear gene mutation, CSE1, caused inositol auxotrophy in yeast cells. The inositol requirement was marked when choline was present in the medium. Inositol-1-phosphate synthase, the regulatory enzyme of inositol synthesis, is repressed by inositol, or more profoundly by a combination of inositol and choline in the wild type. In CSE1, the level of inositol-1-phosphate synthase was low and was...

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Identifiers

PMID: 1587797
DOI: 10.1093/oxfordjournals.jbchem.a123761

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A dominant mutation that alters the regulation of INO1 expression in Saccharomyces cerevisiae.PMID 1587797Read ↗

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Genome-wide screen for inositol auxotrophy in Saccharomyces cerevisiae implicates lipid metabolism in stress response signaling.Semantic proximity Read ↗

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Cloning and sequence of the SCS2 gene, which can suppress the defect of INO1 expression in an inositol auxotrophic mutant of Saccharomyces cerevisiae.Semantic proximity Read ↗

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Regulation of the yeast INO1 gene. The products of the INO2, INO4 and OPI1 regulatory genes are not required for repression in response to inositol.Semantic proximity Read ↗

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