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Article

Progressive dysfunction of twitcher Schwann cells is evaluated better in vitro than in vivo.

Brain research - 21 Feb 1994

Komiyama A, Suzuki K

Abstract excerpt

The twitcher mutant (twi/twi) is an authentic murine model of globoid cell leukodystrophy, a genetic demyelinating disorder, where normally formed myelin degenerates due to a metabolic perturbation of myelin forming cells. We investigated the rate of Schwann cell proliferation in vivo and in vitro using thymidine autoradiography to evaluate cellular function of homozygous twitcher (twi/twi), and heterozygous...

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Identifiers

PMID: 8180787
DOI: 10.1016/0006-8993(94)91222-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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