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Article

Progressive dysfunction of twitcher Schwann cells is evaluated better in vitro than in vivo.

Brain research - 21 Feb 1994

Komiyama A, Suzuki K

Abstract excerpt

The twitcher mutant (twi/twi) is an authentic murine model of globoid cell leukodystrophy, a genetic demyelinating disorder, where normally formed myelin degenerates due to a metabolic perturbation of myelin forming cells. We investigated the rate of Schwann cell proliferation in vivo and in vitro using thymidine autoradiography to evaluate cellular function of homozygous twitcher (twi/twi), and heterozygous...

Topics

Animals
Autoradiography
Cell Division
Cells, Cultured
Genotype
Kinetics
Leukodystrophy, Globoid Cell
Mice
Mice, Inbred C57BL
Mice, Neurologic Mutants
Myelin Sheath
Schwann Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sciatic Nerve

Thymidine

Source

Identifiers

PMID: 8180787
DOI: 10.1016/0006-8993(94)91222-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8180787-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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