Article

Neural stem cell compartments in a mouse model of globoid cell leukodystrophy : implication for therapeutic strategies

2011-01-01

Abstract excerpt

Globoid cell leukodystrophy (GLD) is a rare genetic lysosomal disorder due to deficiency in the B-galactocerebrosidase (GALC) enzyme. GLD affects mainly children; the prognosis is severe, leading to death few years after the diagnosis. Demyelination is believed to occur as a consequence of Psychosine accumulation and neuroinflammation. Clinical observations in GLD babies suggest that GALC deficiency might affect m...

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Literature Corpus work: a6ed6c90-1263-5d26-9ed6-5f682545269d
DOI: 10.21954/ou.ro.0000f186

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