Fate of donor hematopoietic cells in demyelinating mutant mouse, twitcher, following transplantation of GFP+ bone marrow cells.

doi:10.1016/j.nbd.2004.01.002

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Article

Fate of donor hematopoietic cells in demyelinating mutant mouse, twitcher, following transplantation of GFP+ bone marrow cells.

Neurobiology of disease - 1 Jun 2004

Yagi Takashi, McMahon Eileen J, Takikita Shoichi, Mohri Ikuko, Matsushima Glenn K, Suzuki Kinuko

Abstract excerpt

The twitcher mouse is an authentic murine model of a genetic demyelinating disease globoid cell leukodystrophy. Allogeneic bone marrow transplantation (BMT) in twitcher mice resulted in the clinicopathological improvement. Thus, using green fluorescent protein (GFP) transgenic mice as the donor, we investigated the behavior and fate of the donor cells and the possibility of transdifferentiation of the donor cells...

Topics

Animals
Bone Marrow Transplantation
Demyelinating Diseases
Female
Genotype
Green Fluorescent Proteins
Hematopoietic Stem Cell Transplantation
Hematopoietic Stem Cells
Liver
Luminescent Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lung

Male

Mice

Mice, Inbred C57BL

Mice, Neurologic Mutants

Mice, Transgenic

Source

Open in PubMed

Identifiers

PMID: 15207267
DOI: 10.1016/j.nbd.2004.01.002

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